29VJ

Crystal structure of the human METTL3-METTL14 in complex with STM-2457

Summary for 29VJ

• Entry DOI: 10.2210/pdb29vj/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N(6)-adenosine-methyltransferase non-catalytic subunit METTL14, ~{N}-[[6-[(cyclohexylmethylamino)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxidanylidene-1~{H}-pyrido[1,2-a]pyrimidine-2-carboxamide, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, m6a, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 62212.85

Authors

Bedi, R.K.,Caflisch, A. (deposition date: 2026-04-09, release date: 2026-06-24)

• Primary citation: Bedi, R.K.,Caflisch, A.; Crystal structure of the human METTL3-METTL14 in complex with STM-2457; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.11 Å)