28YJ

Molecular basis of ZPD homopolymerization: cryo-EM structure of a native vertebrate egg coat filament

Summary for 28YJ

• Entry DOI: 10.2210/pdb28yj/pdb
• Related: 6TQK 6TQL 7PFP 8BQU 8RKI
• EMDB information: 56971
• Descriptor: Uromodulin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: epidermal growth factor domain, egf domain, zona pellucida module, zona pellucida domain, zp module, zp domain, zp-n domain, zp-c domain, interdomain linker, extracellular matrix, glycoprotein, n-glycan, structural protein, protein filament, protein polymerization, fertilization, egg coat
• Biological source: Gallus gallus (chicken); More
• Total number of polymer chains: 4
• Total formula weight: 152479.69

Authors

Banjara, S.,Okumura, H.,Jovine, L. (deposition date: 2026-03-02, release date: 2026-03-18)

• Primary citation: Fadini, A.,Li, M.,McCoy, A.J.,Banjara, S.,Okumura, H.,Napier, E.,Fontana, P.,Khan, A.R.,Jovine, L.,Terwilliger, T.C.,Read, R.J.,Hekstra, D.R.,AlQuraishi, M.; AlphaFold as a Prior: Experimental Structure Determination Conditioned on a Pretrained Neural Network; To Be Published,

Experimental method

ELECTRON MICROSCOPY (4.6 Å)