274D

CRYSTAL STRUCTURE OF A COVALENT DNA-DRUG ADDUCT: ANTHRAMYCIN BOUND TO C-C-A-A-C-G-T-T-G-G, AND A MOLECULAR EXPLANATION OF SPECIFICITY

Summary for 274D

• Entry DOI: 10.2210/pdb274d/pdb
• Descriptor: DNA (5'-D(*CP*CP*AP*AP*CP*GP*TP*TP*(DRUG)GP*G)-3'), ANTHRAMYCIN (3 entities in total)
• Functional Keywords: b-dna, double helix, complexed with drug, modified, dna
• Total number of polymer chains: 1
• Total formula weight: 3360.33

Authors

Kopka, M.L.,Goodsell, D.S.,Baikalov, I.,Grzeskowiak, K.,Cascio, D.,Dickerson, R.E. (deposition date: 1994-04-28, release date: 1994-10-21, Last modification date: 2024-02-14)

• Primary citation: Kopka, M.L.,Goodsell, D.S.,Baikalov, I.,Grzeskowiak, K.,Cascio, D.,Dickerson, R.E.; Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity.; Biochemistry, 33:13593-13610, 1994; PubMed: 7947769; DOI: 10.1021/bi00250a011

Experimental method

X-RAY DIFFRACTION (2.3 Å)