25IJ

Cryo-EM structure of human Nav1.6 in complex with delta-paraponeritoxin-Pc1a

Summary for 25IJ

• Entry DOI: 10.2210/pdb25ij/pdb
• EMDB information: 80135
• Descriptor: Sodium channel protein type 8 subunit alpha, Delta-paraponeritoxin-Pc1a, Sodium channel regulatory subunit beta-1, ... (9 entities in total)
• Functional Keywords: nav1.6, voltage gated sodium channel, toxin, pc1a, delta-paraponeritoxin-pc1a, transport protein, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 255232.23

Authors

Yang, L.,Fan, X.,Huang, J.,Yan, N. (deposition date: 2026-04-06, release date: 2026-05-20)

• Primary citation: Fan, X.,Jian, H.,Yang, L.,Chen, J.,Wang, H.,Huang, X.,Geng, J.,Wu, Q.,Xie, Y.,Lu, F.,Guo, Q.,Shen, Z.,Jin, X.,Yan, N.; Diverse binding poses of gating modifier neurotoxins as agonists of human Nav1.6; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.1 Å)