25IJ
Cryo-EM structure of human Nav1.6 in complex with delta-paraponeritoxin-Pc1a
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 307 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 179 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=S4 of repeat I","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 87 |
| Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=S4 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S4 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=S4 of repeat IV","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 315 |
| Details | Repeat: {"description":"III","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36823201","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GZ1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"UniProtKB","id":"Q15858","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI31 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI32 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"36823201","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GZ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GZ2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI33 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"36696443","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36823201","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FHD","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8GZ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GZ2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI34 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine","evidences":[{"source":"PubMed","id":"36696443","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36823201","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FHD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GZ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GZ2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI35 |
| Number of Residues | 24 |
| Details | Peptide: {"description":"Delta-paraponeritoxin-Pc1a","featureId":"PRO_0000044538","evidences":[{"source":"PubMed","id":"1685424","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27266841","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI36 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Arginine amide; in delta-paraponeritoxin-Pc1a","evidences":[{"source":"PubMed","id":"1685424","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI37 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30190309","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6AGF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI38 |
| Number of Residues | 128 |
| Details | Domain: {"description":"Ig-like C2-type"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI39 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36696443","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI40 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30190309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36696443","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI41 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36696443","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36823201","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GZ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GZ2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
