25IJ
Cryo-EM structure of human Nav1.6 in complex with delta-paraponeritoxin-Pc1a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium channel protein type 8 subunit alpha | polymer | 1980 | 225520.6 | 1 | UniProt (Q9UQD0) | Homo sapiens (human) | Sodium channel protein type VIII subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.6 |
| 2 | B (B) | Delta-paraponeritoxin-Pc1a | polymer | 26 | 2757.4 | 1 | UniProt (P41736) | Paraponera clavata (Bullet ant Formica clavata) | Delta-PPOTX-Pc1a,Pac-TX,Poneratoxin,PoTX,Poneritoxin |
| 3 | C (C) | Sodium channel regulatory subunit beta-1 | polymer | 173 | 20206.0 | 1 | UniProt (Q07699) | Homo sapiens (human) | |
| 4 | D (D) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB | |||
| 5 | E (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F, G, H, I (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) PubChem (24139) | |||
| 7 | J (A) | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en | non-polymer | 544.8 | 1 | Chemie (9Z9) PubChem (134817783) | |||
| 8 | K, N, O (A) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 3 | Chemie (PCW) | |||
| 9 | L, M (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 2 | Chemie (Y01) PubChem (65082) |
Sequence modifications
B: 1 - 25 (UniProt: P41736)
| PDB | External Database | Details |
|---|---|---|
| Nh2 26 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 248484.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1983.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 4764.5 | |
| All* | Total formula weight | 255232.2 |
