25IJ
Cryo-EM structure of human Nav1.6 in complex with delta-paraponeritoxin-Pc1a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium channel protein type 8 subunit alpha | polymer | 1980 | 225520.6 | 1 | UniProt (Q9UQD0) | Homo sapiens (human) | Sodium channel protein type VIII subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.6 |
| 2 | B (B) | Delta-paraponeritoxin-Pc1a | polymer | 26 | 2757.4 | 1 | UniProt (P41736) | Paraponera clavata (Bullet ant Formica clavata) | Delta-PPOTX-Pc1a,Pac-TX,Poneratoxin,PoTX,Poneritoxin |
| 3 | C (C) | Sodium channel regulatory subunit beta-1 | polymer | 173 | 20206.0 | 1 | UniProt (Q07699) | Homo sapiens (human) | |
| 4 | D (D) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB | |||
| 5 | E (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F, G, H, I (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 7 | J (A) | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en | non-polymer | 544.8 | 1 | Chemie (9Z9) PubChem (134817783) | |||
| 8 | K, N, O (A) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 3 | Chemie (PCW) | |||
| 9 | L, M (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 2 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (57163942) PubChem (45489984) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (155804219) PubChem (169132514) PubChem (60078761) PubChem (73440805) PubChem (99567469) PubChem (65082) PubChem (124301053) PubChem (124302591) PubChem (363416) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (500055) PubChem (124914595) PubChem (124914596) PubChem (13301926) PubChem (13301927) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) |
Sequence modifications
B: 1 - 25 (UniProt: P41736)
| PDB | External Database | Details |
|---|---|---|
| Nh2 26 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 248484.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1983.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 4764.5 | |
| All* | Total formula weight | 255232.2 |
