23XK

Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Cariporide in an outward-open conformation

Summary for 23XK

• Entry DOI: 10.2210/pdb23xk/pdb
• Related: 23XH 23XI
• EMDB information: 69358
• Descriptor: Sodium/hydrogen exchanger 1, N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide (2 entities in total)
• Functional Keywords: sodium/proton antiporter, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 182300.23

Authors

Cong, Y.,Kong, F.,Zhu, A.,Yan, C. (deposition date: 2026-02-24, release date: 2026-04-08)

• Primary citation: Cong, Y.,Kong, F.,Zhu, A.,Yan, C.; Structure and transport mechanism of the human sodium/proton antiporter NHE1; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.1 Å)