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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

23XK

Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Cariporide in an outward-open conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0002026biological_processregulation of the force of heart contraction
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006811biological_processmonoatomic ion transport
A0006883biological_processintracellular sodium ion homeostasis
A0006885biological_processregulation of pH
A0009986cellular_componentcell surface
A0010447biological_processresponse to acidic pH
A0010613biological_processpositive regulation of cardiac muscle hypertrophy
A0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
A0014704cellular_componentintercalated disc
A0015385molecular_functionsodium:proton antiporter activity
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016477biological_processcell migration
A0030011biological_processmaintenance of cell polarity
A0030027cellular_componentlamellipodium
A0030154biological_processcell differentiation
A0030214biological_processhyaluronan catabolic process
A0030307biological_processpositive regulation of cell growth
A0030315cellular_componentT-tubule
A0030346molecular_functionprotein phosphatase 2B binding
A0030674molecular_functionprotein-macromolecule adaptor activity
A0032869biological_processcellular response to insulin stimulus
A0035725biological_processsodium ion transmembrane transport
A0035794biological_processpositive regulation of mitochondrial membrane permeability
A0035994biological_processresponse to muscle stretch
A0036376biological_processsodium ion export across plasma membrane
A0042383cellular_componentsarcolemma
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0045121cellular_componentmembrane raft
A0045760biological_processpositive regulation of action potential
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0051259biological_processprotein complex oligomerization
A0051453biological_processregulation of intracellular pH
A0051492biological_processregulation of stress fiber assembly
A0051893biological_processregulation of focal adhesion assembly
A0060090molecular_functionmolecular adaptor activity
A0070062cellular_componentextracellular exosome
A0070417biological_processcellular response to cold
A0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
A0071236biological_processcellular response to antibiotic
A0071257biological_processcellular response to electrical stimulus
A0071260biological_processcellular response to mechanical stimulus
A0071456biological_processcellular response to hypoxia
A0071468biological_processcellular response to acidic pH
A0071872biological_processcellular response to epinephrine stimulus
A0086003biological_processcardiac muscle cell contraction
A0086036biological_processregulation of cardiac muscle cell membrane potential
A0086092biological_processregulation of the force of heart contraction by cardiac conduction
A0090533cellular_componentcation-transporting ATPase complex
A0098719biological_processsodium ion import across plasma membrane
A0098735biological_processpositive regulation of the force of heart contraction
A1902533biological_processpositive regulation of intracellular signal transduction
A1902600biological_processproton transmembrane transport
A1990351cellular_componenttransporter complex
B0002026biological_processregulation of the force of heart contraction
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005543molecular_functionphospholipid binding
B0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006811biological_processmonoatomic ion transport
B0006883biological_processintracellular sodium ion homeostasis
B0006885biological_processregulation of pH
B0009986cellular_componentcell surface
B0010447biological_processresponse to acidic pH
B0010613biological_processpositive regulation of cardiac muscle hypertrophy
B0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
B0014704cellular_componentintercalated disc
B0015385molecular_functionsodium:proton antiporter activity
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016477biological_processcell migration
B0030011biological_processmaintenance of cell polarity
B0030027cellular_componentlamellipodium
B0030154biological_processcell differentiation
B0030214biological_processhyaluronan catabolic process
B0030307biological_processpositive regulation of cell growth
B0030315cellular_componentT-tubule
B0030346molecular_functionprotein phosphatase 2B binding
B0030674molecular_functionprotein-macromolecule adaptor activity
B0032869biological_processcellular response to insulin stimulus
B0035725biological_processsodium ion transmembrane transport
B0035794biological_processpositive regulation of mitochondrial membrane permeability
B0035994biological_processresponse to muscle stretch
B0036376biological_processsodium ion export across plasma membrane
B0042383cellular_componentsarcolemma
B0042802molecular_functionidentical protein binding
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0045121cellular_componentmembrane raft
B0045760biological_processpositive regulation of action potential
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048306molecular_functioncalcium-dependent protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0051259biological_processprotein complex oligomerization
B0051453biological_processregulation of intracellular pH
B0051492biological_processregulation of stress fiber assembly
B0051893biological_processregulation of focal adhesion assembly
B0060090molecular_functionmolecular adaptor activity
B0070062cellular_componentextracellular exosome
B0070417biological_processcellular response to cold
B0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
B0071236biological_processcellular response to antibiotic
B0071257biological_processcellular response to electrical stimulus
B0071260biological_processcellular response to mechanical stimulus
B0071456biological_processcellular response to hypoxia
B0071468biological_processcellular response to acidic pH
B0071872biological_processcellular response to epinephrine stimulus
B0086003biological_processcardiac muscle cell contraction
B0086036biological_processregulation of cardiac muscle cell membrane potential
B0086092biological_processregulation of the force of heart contraction by cardiac conduction
B0090533cellular_componentcation-transporting ATPase complex
B0098719biological_processsodium ion import across plasma membrane
B0098735biological_processpositive regulation of the force of heart contraction
B1902533biological_processpositive regulation of intracellular signal transduction
B1902600biological_processproton transmembrane transport
B1990351cellular_componenttransporter complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues60
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues34
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues72
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues34
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues56
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues52
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues68
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues58
DetailsTransmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"34108458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DSW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsSite: {"description":"Channel pore-lining","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsSite: {"description":"Not glycosylated"}
ChainResidueDetails

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PDB entries from 2026-05-27

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