1Z3N
Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom
Summary for 1Z3N
Entry DOI | 10.2210/pdb1z3n/pdb |
Related | 1US0 |
Descriptor | aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID, ... (4 entities in total) |
Functional Keywords | oxidoreductase, nadp+, lidorestat |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 37302.39 |
Authors | Van Zandt, M.C.,Jones, M.L.,Gunn, D.E.,Geraci, L.S.,Jones, J.H.,Sawicki, D.R.,Sredy, J.,Jacot, J.L.,Dicioccio, A.T.,Petrova, T.,Mitschler, A.,Podjarny, A.D. (deposition date: 2005-03-14, release date: 2006-03-14, Last modification date: 2024-03-13) |
Primary citation | Van Zandt, M.C.,Jones, M.L.,Gunn, D.E.,Geraci, L.S.,Jones, J.H.,Sawicki, D.R.,Sredy, J.,Jacot, J.L.,Dicioccio, A.T.,Petrova, T.,Mitschler, A.,Podjarny, A.D. Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications J.Med.Chem., 48:3141-3152, 2005 Cited by PubMed: 15857120DOI: 10.1021/jm0492094 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.04 Å) |
Structure validation
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