1Z3N

Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom

1Z3N の概要

• エントリーDOI: 10.2210/pdb1z3n/pdb
• 関連するPDBエントリー: 1US0
• 分子名称: aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, nadp+, lidorestat
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37302.39

構造登録者

Van Zandt, M.C.,Jones, M.L.,Gunn, D.E.,Geraci, L.S.,Jones, J.H.,Sawicki, D.R.,Sredy, J.,Jacot, J.L.,Dicioccio, A.T.,Petrova, T.,Mitschler, A.,Podjarny, A.D. (登録日: 2005-03-14, 公開日: 2006-03-14, 最終更新日: 2024-03-13)

• 主引用文献: Van Zandt, M.C.,Jones, M.L.,Gunn, D.E.,Geraci, L.S.,Jones, J.H.,Sawicki, D.R.,Sredy, J.,Jacot, J.L.,Dicioccio, A.T.,Petrova, T.,Mitschler, A.,Podjarny, A.D.; Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications; J.Med.Chem., 48:3141-3152, 2005; PubMed: 15857120; DOI: 10.1021/jm0492094

実験手法

X-RAY DIFFRACTION (1.04 Å)