1YVJ
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue
Summary for 1YVJ
Entry DOI | 10.2210/pdb1yvj/pdb |
Descriptor | Tyrosine-protein kinase JAK3, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE, ... (4 entities in total) |
Functional Keywords | tyrosine kinase; scid; severe combined immunodeficiency; stat5; stat6; interleukin-2; common-gamma chain, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Endomembrane system; Peripheral membrane protein (By similarity): P52333 |
Total number of polymer chains | 1 |
Total formula weight | 33981.97 |
Authors | Boggon, T.J.,Li, Y.,Manley, P.W.,Eck, M.J. (deposition date: 2005-02-15, release date: 2005-05-24, Last modification date: 2023-11-15) |
Primary citation | Boggon, T.J.,Li, Y.,Manley, P.W.,Eck, M.J. Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog Blood, 106:996-1002, 2005 Cited by PubMed: 15831699DOI: 10.1182/blood-2005-02-0707 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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