1YA3
Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension
Summary for 1YA3
| Entry DOI | 10.2210/pdb1ya3/pdb |
| Descriptor | Mineralocorticoid receptor, PROGESTERONE (3 entities in total) |
| Functional Keywords | mineralocorticoid receptor, steroid receptor, nuclear receptor transcription regulation, activating mutation, hypertension, transcription |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P08235 |
| Total number of polymer chains | 3 |
| Total formula weight | 89876.46 |
| Authors | Fagart, J.,Huyet, J.,Pinon, G.M.,Rochel, M.,Mayer, C.,Rafestin-Oblin, M.E. (deposition date: 2004-12-17, release date: 2005-05-24, Last modification date: 2023-08-23) |
| Primary citation | Fagart, J.,Huyet, J.,Pinon, G.M.,Rochel, M.,Mayer, C.,Rafestin-Oblin, M.E. Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension Nat.Struct.Mol.Biol., 12:554-555, 2005 Cited by PubMed: 15908963DOI: 10.1038/nsmb939 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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