1YA3
Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Mineralocorticoid receptor | polymer | 255 | 29644.4 | 3 | UniProt (P08235) Pfam (PF00104) | Homo sapiens (human) | MR |
| 2 | D, E, F (A, B, C) | PROGESTERONE | non-polymer | 314.5 | 3 | Chemie (STR) PubChem (16219863) PubChem (16401562) PubChem (16757724) PubChem (18635648) PubChem (23615931) PubChem (71200542) PubChem (1807216) PubChem (1807215) PubChem (1807214) PubChem (44135692) PubChem (44275133) PubChem (44279092) PubChem (1201516) PubChem (6603959) PubChem (7004693) PubChem (54269928) PubChem (11869416) PubChem (144033743) PubChem (12303982) PubChem (12303979) PubChem (57526392) PubChem (58483135) PubChem (58766357) PubChem (58872617) PubChem (170068371) PubChem (70865784) PubChem (70987742) PubChem (70987859) PubChem (117072378) PubChem (118670641) PubChem (4920) PubChem (5994) PubChem (123410055) PubChem (92940) PubChem (638017) PubChem (657254) PubChem (1274466) PubChem (5320716) PubChem (6576615) PubChem (7048588) PubChem (7059604) PubChem (7059605) PubChem (7059606) PubChem (7092664) PubChem (7092665) PubChem (129010392) PubChem (7092666) PubChem (9948776) PubChem (11869413) PubChem (11869414) PubChem (11869415) PubChem (11876098) PubChem (11876099) PubChem (11876100) PubChem (12303971) PubChem (12303981) PubChem (12303986) PubChem (12303989) PubChem (12303992) PubChem (134688829) PubChem (135189961) PubChem (135190011) PubChem (135249041) PubChem (142168519) PubChem (142402781) PubChem (145130068) PubChem (163070289) PubChem (163070290) PubChem (163070291) PubChem (163070292) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
A, B, C: 731 - 984 (UniProt: P08235)
| PDB | External Database | Details |
|---|---|---|
| Ser 730 | - | cloning artifact |
| Leu 810 | Ser 810 | engineered mutation |
| Ala 910 | Cys 910 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 88933.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 943.4 | |
| All* | Total formula weight | 89876.5 |
