1YA3
Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Mineralocorticoid receptor | polymer | 255 | 29644.4 | 3 | UniProt (P08235) Pfam (PF00104) | Homo sapiens (human) | MR |
| 2 | D, E, F (A, B, C) | PROGESTERONE | non-polymer | 314.5 | 3 | Chemie (STR) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
A, B, C: 731 - 984 (UniProt: P08235)
| PDB | External Database | Details |
|---|---|---|
| Ser 730 | - | cloning artifact |
| Leu 810 | Ser 810 | engineered mutation |
| Ala 910 | Cys 910 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 88933.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 943.4 | |
| All* | Total formula weight | 89876.5 |
