1XDS

Crystal structure of Aclacinomycin-10-hydroxylase (RdmB) in complex with S-adenosyl-L-methionine (SAM) and 11-deoxy-beta-rhodomycin (DbrA)

1XDS の概要

• エントリーDOI: 10.2210/pdb1xds/pdb
• 関連するPDBエントリー: 1QZZ 1R00 1TW3 1XDU
• 分子名称: Protein RdmB, S-ADENOSYLMETHIONINE, 11-DEOXY-BETA-RHODOMYCIN, ... (4 entities in total)
• 機能のキーワード: anthracycline; hydroxylase; s-adenosyl-l-methionine; streptomyces; polyketide antibiotics; divergent evolution, structural proteomics in europe, spine, structural genomics, transferase
• 由来する生物種: Streptomyces purpurascens
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82668.95

構造登録者

Jansson, A.,Koskiniemi, H.,Erola, A.,Wang, J.,Mantsala, P.,Schneider, G.,Niemi, J.,Structural Proteomics in Europe (SPINE) (登録日: 2004-09-08, 公開日: 2004-11-23, 最終更新日: 2024-04-03)

• 主引用文献: Jansson, A.,Koskiniemi, H.,Erola, A.,Wang, J.,Schneider, G.,Niemi, J.; Aclacinomycin 10-Hydroxylase Is a Novel Substrate-assisted Hydroxylase Requiring S-Adenosyl-L-methionine as Cofactor; J.Biol.Chem., 280:3636-3644, 2005; PubMed: 15548527; DOI: 10.1074/jbc.M412095200

実験手法

X-RAY DIFFRACTION (2.3 Å)