1XDU

Crystal structure of Aclacinomycin-10-hydroxylase (RdmB) in complex with Sinefungin (SFG)

Summary for 1XDU

Entry DOI	10.2210/pdb1xdu/pdb
Related	1QZZ 1R00 1TW3 1XDS
Descriptor	Protein RdmB, ACETATE ION, SINEFUNGIN, ... (4 entities in total)
Functional Keywords	anthracycline; hydroxylase; s-adenosyl-l-methionine analogue; sinefungin; streptomyces; polyketide antibiotics; divergent evolution, transferase
Biological source	Streptomyces purpurascens
Total number of polymer chains	1
Total formula weight	40606.64
Authors	Jansson, A.,Koskiniemi, H.,Erola, A.,Wang, J.,Mantsala, P.,Schneider, G.,Niemi, J. (deposition date: 2004-09-08, release date: 2004-11-23, Last modification date: 2024-04-03)
Primary citation	Jansson, A.,Koskiniemi, H.,Erola, A.,Wang, J.,Schneider, G.,Niemi, J. Aclacinomycin 10-Hydroxylase Is a Novel Substrate-assisted Hydroxylase Requiring S-Adenosyl-L-methionine as Cofactor J.Biol.Chem., 280:3636-3644, 2005 Cited by PubMed: 15548527 DOI: 10.1074/jbc.M412095200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation