1WZY

Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative

Summary for 1WZY

Entry DOI	10.2210/pdb1wzy/pdb
Descriptor	Mitogen-activated protein kinase 1, 1-ALLYL-5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE (3 entities in total)
Functional Keywords	erk2, inhibitor, kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, spindle : P28482
Total number of polymer chains	1
Total formula weight	42598.85
Authors	Kinoshita, T. (deposition date: 2005-03-10, release date: 2005-12-20, Last modification date: 2024-03-13)
Primary citation	Kinoshita, T.,Warizaya, M.,Ohori, M.,Sato, K.,Neya, M.,Fujii, T. Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative Bioorg.Med.Chem.Lett., 16:55-58, 2006 Cited by PubMed: 16242327 DOI: 10.1016/j.bmcl.2005.09.055 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation