1WZY
Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitogen-activated protein kinase 1 | polymer | 368 | 42231.4 | 1 | UniProt (P28482) Pfam (PF00069) In PDB | Homo sapiens (human) | Extracellular signal-regulated kinase 2, ERK-2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1 |
| 2 | A | 1-ALLYL-5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE | non-polymer | 367.4 | 1 | Chemie (F29) | |||
| 3 | water | water | 18.0 | 241 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: P28482)
| PDB | External Database | Details |
|---|---|---|
| Gly -7 | - | cloning artifact |
| Asp -6 | - | cloning artifact |
| Leu -5 | - | cloning artifact |
| Gly -4 | - | cloning artifact |
| Ser -3 | - | cloning artifact |
| Asp -2 | - | cloning artifact |
| Glu -1 | - | cloning artifact |
| Leu 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42231.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 367.4 | |
| All* | Total formula weight | 42598.8 |
