1W88

The crystal structure of pyruvate dehydrogenase E1(D180N,E183Q) bound to the peripheral subunit binding domain of E2

Summary for 1W88

Entry DOI	10.2210/pdb1w88/pdb
Related	1B5S 1EBD 1LAB 1LAC 1W3D 1W4E 1W4F 1W4G 1W4H 1W85 2PDD 2PDE
Descriptor	PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT, PYRUVATE DEHYDROGENASE E1 COMPONENT, BETA SUBUNIT, DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE, ... (6 entities in total)
Functional Keywords	pyruvate dehydrogenase, dihydrolipoyl, acetyl transferase, multienzyme complex, oxidoreductase, transferase, catalysis, slinky
Biological source	GEOBACILLUS STEAROTHERMOPHILUS More
Total number of polymer chains	10
Total formula weight	319320.48
Authors	Frank, R.A.W.,Pratap, J.V.,Pei, X.Y.,Perham, R.N.,Luisi, B.F. (deposition date: 2004-09-16, release date: 2004-11-02, Last modification date: 2023-12-13)
Primary citation	Frank, R.A.W.,Titman, C.M.,Pratap, J.V.,Luisi, B.F.,Perham, R.N. A Molecular Switch and Proton-Wire Synchronize the Active Sites in Thiamine-Dependent Enzymes Science, 306:872-, 2004 Cited by PubMed: 15514159 DOI: 10.1126/SCIENCE.1101030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation