1W88
The crystal structure of pyruvate dehydrogenase E1(D180N,E183Q) bound to the peripheral subunit binding domain of E2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT | polymer | 368 | 41385.0 | 4 | UniProt (P21873) Pfam (PF00676) | GEOBACILLUS STEAROTHERMOPHILUS | |
| 2 | B, D, F, H (B, D, F, H) | PYRUVATE DEHYDROGENASE E1 COMPONENT, BETA SUBUNIT | polymer | 324 | 35364.4 | 4 | UniProt (P21874) Pfam (PF02779) Pfam (PF02780) | GEOBACILLUS STEAROTHERMOPHILUS | |
| 3 | I, J (I, J) | DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE | polymer | 49 | 5262.1 | 2 | UniProt (P11961) Pfam (PF02817) | GEOBACILLUS STEAROTHERMOPHILUS | E2, DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX |
| 4 | K, M, O, Q (A, C, E, G) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | L, N, P, R (A, C, E, G) | THIAMINE DIPHOSPHATE | non-polymer | 425.3 | 4 | Chemie (TPP) | |||
| 6 | AA, BA, S, T, U... (I, J, A, B, C...) | water | water | 18.0 | 1173 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 1 - 368 (UniProt: P21873)
| PDB | External Database | Details |
|---|---|---|
| Asn 180 | Asp 180 | engineered mutation |
| Gln 183 | Glu 183 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 317522.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1798.5 | |
| All* | Total formula weight | 319320.5 |
