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2E1W

Crystal structure of adenosine deaminase complexed with potent inhibitors

Replaces:  1V78
Summary for 2E1W
Entry DOI10.2210/pdb2e1w/pdb
Related1V79 1V7A
DescriptorAdenosine deaminase, ZINC ION, 1-{(1R,2S)-2-HYDROXY-1-[2-(1-NAPHTHYL)ETHYL]PROPYL}-1H-IMIDAZOLE-4-CARBOXAMIDE, ... (4 entities in total)
Functional Keywordsbeta barrel, zinc, hydrolase
Biological sourceBos taurus (cattle)
Cellular locationCell membrane; Peripheral membrane protein; Extracellular side (By similarity): P56658
Total number of polymer chains1
Total formula weight40730.47
Authors
Kinoshita, T. (deposition date: 2006-10-30, release date: 2006-11-07, Last modification date: 2024-03-13)
Primary citationTerasaka, T.,Okumura, H.,Tsuji, K.,Kato, T.,Nakanishi, I.,Kinoshita, T.,Kato, Y.,Kuno, M.,Seki, N.,Naoe, Y.,Inoue, T.,Tanaka, K.,Nakamura, K.
Structure-Based Design and Synthesis of Non-Nucleoside, Potent, and Orally Bioavailable Adenosine Deaminase Inhibitors
J.Med.Chem., 47:2728-2731, 2004
Cited by
PubMed: 15139750
DOI: 10.1021/jm0499559
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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