1UYG

Human Hsp90-alpha with 8-(2,5-dimethoxy-benzyl)-2-fluoro-9H-purin-6-ylamine

Summary for 1UYG

Related1BYQ 1OSF 1YER 1YES 1YET 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYH 1UYI 1UYK 1UYL 1UYM
DescriptorHEAT SHOCK PROTEIN HSP 90-ALPHA, 8-(2,5-DIMETHOXY-BENZYL)-2-FLUORO-9H-PURIN-6-YLAMINE (3 entities in total)
Functional Keywordshsp90, atpase, pu2, chaperone, atp-binding, heat shock
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm  P07900
Total number of polymer chains1
Total molecular weight26905.07
Authors
Primary citation
Wright, L.,Barril, X.,Dymock, B.,Sheridan, L.,Surgenor, A.,Beswick, M.,Drysdale, M.,Collier, A.,Massey, A.,Davies, N.,Fink, A.,Fromont, C.,Aherne, W.,Boxall, K.,Sharp, S.,Workman, P.,Hubbard, R.E.
Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11:775-, 2004
PubMed: 15217611 (PDB entries with the same primary citation)
DOI: 10.1016/J.CHEMBIOL.2004.03.033
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.28460.5%4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution