1UYG

Human Hsp90-alpha with 8-(2,5-dimethoxy-benzyl)-2-fluoro-9H-purin-6-ylamine

Summary for 1UYG

Entry DOI	10.2210/pdb1uyg/pdb
Related	1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYH 1UYI 1UYK 1UYL 1UYM 1YER 1YES 1YET
Descriptor	HEAT SHOCK PROTEIN HSP 90-ALPHA, 8-(2,5-DIMETHOXY-BENZYL)-2-FLUORO-9H-PURIN-6-YLAMINE (3 entities in total)
Functional Keywords	hsp90, atpase, pu2, chaperone, atp-binding, heat shock
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : P07900
Total number of polymer chains	1
Total formula weight	26905.07
Authors	Wright, L.,Barril, X.,Dymock, B.,Sheridan, L.,Surgenor, A.,Beswick, M.,Drysdale, M.,Collier, A.,Massey, A.,Davies, N.,Fink, A.,Fromont, C.,Aherne, W.,Boxall, K.,Sharp, S.,Workman, P.,Hubbard, R.E. (deposition date: 2004-03-02, release date: 2004-07-01, Last modification date: 2023-12-13)
Primary citation	Wright, L.,Barril, X.,Dymock, B.,Sheridan, L.,Surgenor, A.,Beswick, M.,Drysdale, M.,Collier, A.,Massey, A.,Davies, N.,Fink, A.,Fromont, C.,Aherne, W.,Boxall, K.,Sharp, S.,Workman, P.,Hubbard, R.E. Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms Chem.Biol., 11:775-, 2004 Cited by PubMed: 15217611 DOI: 10.1016/J.CHEMBIOL.2004.03.033 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation