1UYE

Human Hsp90-alpha with 8-(2-chloro-3,4,5-trimethoxy-benzyl)-9-pent-4-ylnyl-9H-purin-6-ylamine

1UYE の概要

関連するPDBエントリー1BYQ 1OSF 1YER 1YES 1YET 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1UYM
分子名称HEAT SHOCK PROTEIN HSP 90-ALPHA, 8-(2-CHLORO-3,4,5-TRIMETHOXY-BENZYL)-9-PENT-4-YLNYL-9H-PURIN-6-YLAMINE (3 entities in total)
機能のキーワードhsp90, atpase, pu9, chaperone, atp-binding, heat shock
由来する生物種HOMO SAPIENS (HUMAN)
細胞内の位置Cytoplasm  P07900
ポリマー鎖数1
分子量合計27017.65
構造登録者
主引用文献
Wright, L.,Barril, X.,Dymock, B.,Sheridan, L.,Surgenor, A.,Beswick, M.,Drysdale, M.,Collier, A.,Massey, A.,Davies, N.,Fink, A.,Fromont, C.,Aherne, W.,Boxall, K.,Sharp, S.,Workman, P.,Hubbard, R.E.
Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11:775-, 2004
PubMed: 15217611 (主引用文献が同じPDBエントリー)
DOI: 10.1016/J.CHEMBIOL.2004.03.033
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2 Å)
NMR情報
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25180.5%2.2%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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