1T05
HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate
Summary for 1T05
Entry DOI | 10.2210/pdb1t05/pdb |
Related | 1RTD 1T03 |
Descriptor | oligonucleotide template, oligonucleotide primer, POL polyprotein, ... (8 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, tenofovir, rt-dna complex, transferase-dna complex, transferase/dna |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P04585 |
Total number of polymer chains | 4 |
Total formula weight | 131187.19 |
Authors | Tuske, S.,Sarafianos, S.G.,Ding, J.,Arnold, E. (deposition date: 2004-04-07, release date: 2004-05-11, Last modification date: 2023-08-23) |
Primary citation | Tuske, S.,Sarafianos, S.G.,Clark Jr., A.D.,Ding, J.,Naeger, L.K.,White, K.L.,Miller, M.D.,Gibbs, C.S.,Boyer, P.L.,Clark, P.,Wang, G.,Gaffney, B.L.,Jones, R.A.,Jerina, D.M.,Hughes, S.H.,Arnold, E. Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir Nat.Struct.Mol.Biol., 11:469-474, 2004 Cited by PubMed: 15107837DOI: 10.1038/nsmb760 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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