1SQ0

Crystal Structure of the Complex of the Wild-type Von Willebrand Factor A1 domain and Glycoprotein Ib alpha at 2.6 Angstrom Resolution

1SQ0 の概要

• エントリーDOI: 10.2210/pdb1sq0/pdb
• 関連するPDBエントリー: 1AUQ 1M0Z 1M10 1OOK 1P8V
• 分子名称: Von Willebrand factor (vWF) [Contains: Von Willebrand antigen II], Platelet glycoprotein Ib alpha chain (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (CD42B-alpha) (CD42B) [Contains: Glycocalicin] (3 entities in total)
• 機能のキーワード: leucine rich repeat (lrr), right-handed beta-alpha superhelix); integrin a (or i) domain fold, blood clotting
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P04275; Membrane; Single-pass type I membrane protein: P07359
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 56550.86

構造登録者

Dumas, J.J.,Kumar, R.,McDonagh, T.,Sullivan, F.,Stahl, M.L.,Somers, W.S.,Mosyak, L. (登録日: 2004-03-17, 公開日: 2004-04-13, 最終更新日: 2021-10-27)

• 主引用文献: Dumas, J.J.,Kumar, R.,McDonagh, T.,Sullivan, F.,Stahl, M.L.,Somers, W.S.,Mosyak, L.; Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations; J.Biol.Chem., 279:23327-23334, 2004; PubMed: 15039442; DOI: 10.1074/jbc.M401659200

実験手法

X-RAY DIFFRACTION (2.6 Å)