1SCN

INACTIVATION OF SUBTILISIN CARLSBERG BY N-(TERT-BUTOXYCARBONYL-ALANYL-PROLYL-PHENYLALANYL)-O-BENZOL HYDROXYLAMINE: FORMATION OF COVALENT ENZYME-INHIBITOR LINKAGE IN THE FORM OF A CARBAMATE DERIVATIVE

Summary for 1SCN

Related PRD IDPRD_000260
DescriptorSUBTILISIN CARLSBERG, N-(tert-butoxycarbonyl)-L-alanyl-N-[(1R)-1-(carboxyamino)-2-phenylethyl]-L-prolinamide, CALCIUM ION, ... (5 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, serine proteinase, hydrolase/hydrolase inhibitor
Biological sourceBacillus licheniformis
Cellular locationSecreted P00780
Total number of polymer chains1
Total molecular weight28026.05
Authors
Steinmetz, A.C.U.,Demuth, H.-U.,Ringe, D. (deposition date: 1994-03-02, release date: 1994-08-31, Last modification date: 2017-11-29)
Primary citation
Steinmetz, A.C.,Demuth, H.U.,Ringe, D.
Inactivation of subtilisin Carlsberg by N-((tert-butoxycarbonyl)alanylprolylphenylalanyl)-O-benzolhydroxyl- amine: formation of a covalent enzyme-inhibitor linkage in the form of a carbamate derivative.
Biochemistry, 33:10535-10544, 1994
PubMed: 8068694 (PDB entries with the same primary citation)
DOI: 10.1021/bi00200a040
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers190 5.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-09-23