1S0I

Trypanosoma cruzi trans-sialidase in complex with sialyl-lactose (Michaelis complex)

Summary for 1S0I

Entry DOI	10.2210/pdb1s0i/pdb
Related	1S0J 1S0K
Related PRD ID	PRD_900025
Descriptor	trans-sialidase, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose (3 entities in total)
Functional Keywords	transglycosidase, sialyllactose, trypanosoma cruzi, michaelis complex, hydrolase
Biological source	Trypanosoma cruzi
Total number of polymer chains	1
Total formula weight	71978.80
Authors	Amaya, M.F.,Watts, A.G.,Damager, I.,Wehenkel, A.,Nguyen, T.,Buschiazzo, A.,Paris, G.,Frasch, A.C.,Withers, S.G.,Alzari, P.M. (deposition date: 2003-12-31, release date: 2004-05-18, Last modification date: 2023-08-23)
Primary citation	Amaya, M.F.,Watts, A.G.,Damager, I.,Wehenkel, A.,Nguyen, T.,Buschiazzo, A.,Paris, G.,Frasch, A.C.,Withers, S.G.,Alzari, P.M. Structural Insights into the Catalytic Mechanism of Trypanosoma cruzi trans-Sialidase. Structure, 12:775-784, 2004 Cited by PubMed: 15130470 DOI: 10.1016/j.str.2004.02.036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation