1RZI

Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab

Summary for 1RZI

• Entry DOI: 10.2210/pdb1rzi/pdb
• Related: 1RZ7 1RZ8 1RZF 1RZG 1RZJ 1RZK
• Descriptor: Fab 47e light chain, Fab 47e heavy chain (3 entities in total)
• Functional Keywords: hiv-1; gp120; cd4i; antibodies; tyrosine sulfation; vh-gene usage, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 16
• Total formula weight: 378596.51

Authors

Huang, C.C.,Venturi, M.,Majeed, S.,Moore, M.J.,Phogat, S.,Zhang, M.-Y.,Dimitrov, D.S.,Hendrickson, W.A.,Robinson, J.,Sodroski, J.,Wyatt, R.,Choe, H.,Farzan, M.,Kwong, P.D. (deposition date: 2003-12-24, release date: 2004-02-03, Last modification date: 2011-07-13)

• Primary citation: Huang, C.C.,Venturi, M.,Majeed, S.,Moore, M.J.,Phogat, S.,Zhang, M.-Y.,Dimitrov, D.S.,Hendrickson, W.A.,Robinson, J.,Sodroski, J.,Wyatt, R.,Choe, H.,Farzan, M.,Kwong, P.D.; Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120; Proc.Natl.Acad.Sci.USA, 101:2706-2711, 2004; PubMed: 14981267; DOI: 10.1073/pnas.0308527100

Experimental method

X-RAY DIFFRACTION (2.9 Å)