Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I

Summary for 1RR8

Descriptor5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I, ... (6 entities in total)
Functional Keywordsprotein-dna complex, topotecan, camptothecin, nucleic acid, human topoisomerase i, isomerase-dna complex, isomerase/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleolus P11387
Total number of polymer chains3
Total molecular weight81144.59
Chrencik, J.E.,Staker, B.L.,Burgin, A.B.,Stewart, L.,Redinbo, M.R. (deposition date: 2003-12-08, release date: 2004-07-06, Last modification date: 2011-07-13)
Primary citation
Chrencik, J.E.,Staker, B.L.,Burgin, A.B.,Pourquier, P.,Pommier, Y.,Stewart, L.,Redinbo, M.R.
Mechanisms of camptothecin resistance by human topoisomerase I mutations
J.Mol.Biol., 339:773-784, 2004
PubMed: 15165849 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2004.03.077
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers90.6%4.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report