Summary for 1RR8
| Descriptor | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I, ... (6 entities in total) |
|---|---|
| Functional Keywords | protein-dna complex, topotecan, camptothecin, nucleic acid, human topoisomerase i, isomerase-dna complex, isomerase/dna |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus, nucleolus P11387 |
| Total number of polymer chains | 3 |
| Total molecular weight | 81144.59 |
| Authors | Chrencik, J.E.,Staker, B.L.,Burgin, A.B.,Stewart, L.,Redinbo, M.R. (deposition date: 2003-12-08, release date: 2004-07-06, Last modification date: 2011-07-13) |
| Primary citation | Chrencik, J.E.,Staker, B.L.,Burgin, A.B.,Pourquier, P.,Pommier, Y.,Stewart, L.,Redinbo, M.R. Mechanisms of camptothecin resistance by human topoisomerase I mutations J.Mol.Biol., 339:773-784, 2004 PubMed: 15165849 (PDB entries with the same primary citation) DOI: 10.1016/j.jmb.2004.03.077  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
