deoxyhypusine synthase holoenzyme in its low ionic strength, high pH crystal form with the inhibitor GC7 bound in the active site

Summary for 1RQD
Related1DHS 1RLZ 1ROZ
DescriptorDeoxyhypusine synthase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1-GUANIDINIUM-7-AMINOHEPTANE (3 entities in total)
Functional Keywordsrossmann fold, nad cofactor, deoxyhypusine, hypusine, spermidine, gc7, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight83700.29
Umland, T.C.,Wolff, E.C.,Park, M.-H.,Davies, D.R. (deposition date: 2003-12-04, release date: 2004-07-13, Last modification date: 2014-11-12)
Primary citationDavies, D.R.,Park, M.-H.,Umland, T.C.,Wolff, E.C.
A New Crystal Structure of Deoxyhypusine Synthase Reveals the Configuration of the Active Enzyme and of an Enzyme-NAD-Inhibitor Ternary Complex
J.Biol.Chem., 279:28697-28705, 2004
PubMed: 15100216
DOI: 110.1074/jbc.M404095200
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-16