1RQD

deoxyhypusine synthase holoenzyme in its low ionic strength, high pH crystal form with the inhibitor GC7 bound in the active site

Summary for 1RQD

Entry DOI	10.2210/pdb1rqd/pdb
Related	1DHS 1RLZ 1ROZ
Descriptor	Deoxyhypusine synthase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1-GUANIDINIUM-7-AMINOHEPTANE (3 entities in total)
Functional Keywords	rossmann fold, nad cofactor, deoxyhypusine, hypusine, spermidine, gc7, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	83700.29
Authors	Umland, T.C.,Wolff, E.C.,Park, M.-H.,Davies, D.R. (deposition date: 2003-12-04, release date: 2004-07-13, Last modification date: 2023-08-23)
Primary citation	Umland, T.C.,Wolff, E.C.,Park, M.-H.,Davies, D.R. A New Crystal Structure of Deoxyhypusine Synthase Reveals the Configuration of the Active Enzyme and of an Enzyme-NAD-Inhibitor Ternary Complex J.Biol.Chem., 279:28697-28705, 2004 Cited by PubMed: 15100216 DOI: 10.1074/jbc.M404095200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation