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1RDT

Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer

Summary for 1RDT
Entry DOI10.2210/pdb1rdt/pdb
Related1FM6 1FM9
DescriptorRetinoic acid receptor RXR-alpha, LxxLL motif coactivator, Peroxisome proliferator activated receptor gamma, ... (7 entities in total)
Functional Keywordshormone, receptor, polymorphism, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: P19793 P37231
Total number of polymer chains4
Total formula weight65772.21
Authors
Haffner, C.D.,Lenhard, J.M.,Miller, A.B.,McDougald, D.L.,Dwornik, K.,Ittoop, O.R.,Gampe Jr., R.T.,Xu, H.E.,Blanchard, S.,Montana, V.G. (deposition date: 2003-11-06, release date: 2004-11-09, Last modification date: 2023-08-23)
Primary citationHaffner, C.D.,Lenhard, J.M.,Miller, A.B.,McDougald, D.L.,Dwornik, K.,Ittoop, O.R.,Gampe Jr., R.T.,Xu, H.E.,Blanchard, S.,Montana, V.G.,Consler, T.G.,Bledsoe, R.K.,Ayscue, A.,Croom, D.
Structure-based design of potent retinoid X receptor alpha agonists.
J.Med.Chem., 47:2010-2029, 2004
Cited by
PubMed: 15056000
DOI: 10.1021/jm030565g
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

數據於2024-03-27公開中

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