1Q4V

CRYSTAL STRUCTURE OF ALLO-ILEA2-INSULIN, AN INACTIVE CHIRAL ANALOGUE: IMPLICATIONS FOR THE MECHANISM OF RECEPTOR

Replaces:  1PC1

Summary for 1Q4V

Related1TRZ
DescriptorInsulin, ZINC ION, PHENOL, ... (5 entities in total)
Functional Keywordsallo-ile-a2-insulin, protein unfolding, insulin receptor, hormone-growth factor complex, hormone/growth factor
Total number of polymer chains4
Total molecular weight11860.23
Authors
Wan, Z.L.,Xu, B.,Chu, Y.C.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2003-08-04, release date: 2003-08-19, Last modification date: 2011-07-13)
Primary citation
Wan, Z.L.,Xu, B.,Chu, Y.C.,Katsoyannis, P.G.,Weiss, M.A.
Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding.
Biochemistry, 42:12770-12783, 2003
PubMed: 14596591 (PDB entries with the same primary citation)
DOI: 10.1021/bi034430o
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers42.2%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report