1QZR

CRYSTAL STRUCTURE OF THE ATPASE REGION OF SACCHAROMYCES CEREVISIAE TOPOISOMERASE II BOUND TO ICRF-187 (DEXRAZOXANE)

Replaces:  1Q1D

Summary for 1QZR

• Entry DOI: 10.2210/pdb1qzr/pdb
• Related: 1BGW 1BJT 1PVG
• Descriptor: DNA topoisomerase II, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• Functional Keywords: ghkl atpase domain, icrf, icrf-187, dexrazoxane, isomerase
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Cellular location: Nucleus: P06786
• Total number of polymer chains: 2
• Total formula weight: 97527.15

Authors

Classen, S.,Olland, S.,Berger, J.M. (deposition date: 2003-09-17, release date: 2003-09-30, Last modification date: 2023-08-23)

• Primary citation: Classen, S.,Olland, S.,Berger, J.M.; Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187; Proc.Natl.Acad.Sci.USA, 100:10629-10634, 2003; PubMed: 12963818; DOI: 10.1073/pnas.1832879100

Experimental method

X-RAY DIFFRACTION (1.9 Å)