Crystal Structure of E. coli purine nucleoside phosphorylase complexed with 2-fluoro-2'-deoxyadenosine and sulfate/phosphate

Summary for 1PKE

Related1ECP 1PK7 1K9S 3PNP 1ODJ
DescriptorPurine nucleoside phosphorylase DeoD-type, PHOSPHATE ION, 5-(6-AMINO-2-FLUORO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL, ... (4 entities in total)
Functional Keywordshexamer, protein-nucleoside complex, trimer of dimers, transferase
Biological sourceEscherichia coli O157:H7
Total number of polymer chains3
Total molecular weight78257.51
Bennett, E.M.,Li, C.,Allan, P.W.,Parker, W.B.,Ealick, S.E. (deposition date: 2003-06-05, release date: 2003-11-25, Last modification date: 2019-12-11)
Primary citation
Bennett, E.M.,Li, C.,Allan, P.W.,Parker, W.B.,Ealick, S.E.
Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase.
J.Biol.Chem., 278:47110-47118, 2003
PubMed: 12937174 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M304622200
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.18410 0.4% 3.9% 3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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