1P19

Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, in complex with the product IMP

Summary for 1P19

Entry DOI	10.2210/pdb1p19/pdb
Related	1p17 1p18 1tc1 1tc2
Descriptor	hypoxanthine phosphoribosyltransferase, INOSINIC ACID (3 entities in total)
Functional Keywords	transferase, glycosyltransferase, phosphoribosyltransferase, nucleotide metabolism, purine salvage, product complex
Biological source	Trypanosoma cruzi
Total number of polymer chains	4
Total formula weight	103774.44
Authors	Medrano, F.J.,Eakin, A.E.,Craig III, S.P. (deposition date: 2003-04-11, release date: 2004-05-18, Last modification date: 2024-02-14)
Primary citation	Canyuk, B.,Medrano, F.J.,Wenck, M.A.,Focia, P.J.,Eakin, A.E.,Craig III, S.P. Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase. J.Mol.Biol., 335:905-921, 2004 Cited by PubMed: 14698288 DOI: 10.1016/j.jmb.2003.11.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation