1P19
Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, in complex with the product IMP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006166 | biological_process | purine ribonucleoside salvage |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0032264 | biological_process | IMP salvage |
A | 0046872 | molecular_function | metal ion binding |
A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006166 | biological_process | purine ribonucleoside salvage |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0032264 | biological_process | IMP salvage |
B | 0046872 | molecular_function | metal ion binding |
B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
C | 0000166 | molecular_function | nucleotide binding |
C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006166 | biological_process | purine ribonucleoside salvage |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0032264 | biological_process | IMP salvage |
C | 0046872 | molecular_function | metal ion binding |
C | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
D | 0000166 | molecular_function | nucleotide binding |
D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006166 | biological_process | purine ribonucleoside salvage |
D | 0016757 | molecular_function | glycosyltransferase activity |
D | 0032264 | biological_process | IMP salvage |
D | 0046872 | molecular_function | metal ion binding |
D | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE IMP A 1300 |
Chain | Residue |
A | GLU111 |
A | VAL165 |
A | ASP171 |
A | HOH1307 |
A | HOH1373 |
A | ASP112 |
A | VAL114 |
A | ASP115 |
A | THR116 |
A | ALA117 |
A | LYS143 |
A | ALA163 |
A | PHE164 |
site_id | AC2 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE IMP B 2300 |
Chain | Residue |
B | GLU111 |
B | ASP112 |
B | ILE113 |
B | VAL114 |
B | ASP115 |
B | THR116 |
B | ALA117 |
B | THR119 |
B | LYS143 |
B | ALA163 |
B | PHE164 |
B | VAL165 |
B | ASP171 |
B | HOH2317 |
B | HOH2362 |
B | HOH2436 |
site_id | AC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE IMP C 3300 |
Chain | Residue |
C | ASP112 |
C | ILE113 |
C | THR116 |
C | ALA117 |
C | THR119 |
C | LYS143 |
C | ALA163 |
C | PHE164 |
C | VAL165 |
C | LEU170 |
C | ASP171 |
C | HOH3343 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE IMP D 4300 |
Chain | Residue |
D | GLU111 |
D | ASP112 |
D | ILE113 |
D | ASP115 |
D | THR116 |
D | ALA117 |
D | LEU118 |
D | THR119 |
D | LYS143 |
D | ALA163 |
D | VAL165 |
D | ASP171 |
D | HOH4400 |
Functional Information from PROSITE/UniProt
site_id | PS00103 |
Number of Residues | 13 |
Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIVDTAlT |
Chain | Residue | Details |
A | VAL107-THR119 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a95 |
Chain | Residue | Details |
A | GLU111 | |
A | LYS143 | |
A | ASP112 | |
A | ASP115 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a95 |
Chain | Residue | Details |
B | GLU111 | |
B | LYS143 | |
B | ASP112 | |
B | ASP115 |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a95 |
Chain | Residue | Details |
C | GLU111 | |
C | LYS143 | |
C | ASP112 | |
C | ASP115 |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a95 |
Chain | Residue | Details |
D | GLU111 | |
D | LYS143 | |
D | ASP112 | |
D | ASP115 |
site_id | CSA5 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1a95 |
Chain | Residue | Details |
A | GLU111 | |
A | LYS143 | |
A | ASP112 | |
A | ARG147 | |
A | ASP115 |
site_id | CSA6 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1a95 |
Chain | Residue | Details |
B | GLU111 | |
B | LYS143 | |
B | ASP112 | |
B | ARG147 | |
B | ASP115 |
site_id | CSA7 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1a95 |
Chain | Residue | Details |
C | GLU111 | |
C | LYS143 | |
C | ASP112 | |
C | ARG147 | |
C | ASP115 |
site_id | CSA8 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1a95 |
Chain | Residue | Details |
D | GLU111 | |
D | LYS143 | |
D | ASP112 | |
D | ARG147 | |
D | ASP115 |