1OWH

Substituted 2-Naphthamidine Inhibitors of Urokinase

Summary for 1OWH
Related1FV9 1OWD 1OWE 1OWI 1OWJ 1OWK
DescriptorUrokinase-type plasminogen activator, SULFATE ION, 6-[(Z)-AMINO(IMINO)METHYL]-N-[4-(AMINOMETHYL)PHENYL]-2-NAPHTHAMIDE, ... (4 entities in total)
Functional Keywordsplasminogen activation, hydrolase, serine protease, glycoprotein, kringle, egf-like domain
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P00749
Total number of polymer chains1
Total formula weight28243.08
Authors
Wendt, M.D.,Rockway, T.W.,Geyer, A.,McClellan, W.,Weitzberg, M.,Zhao, X.,Mantei, R.,Nienaber, V.L.,Stewart, K.,Klinghofer, V.,Giranda, V.L. (deposition date: 2003-03-28, release date: 2003-09-30, Last modification date: 2017-10-11)
Primary citationGeyer, A.,Giranda, V.L.,Klinghofer, V.,Mantei, R.,McClellan, W.,Nienaber, V.L.,Rockway, T.W.,Stewart, K.,Weitzberg, M.,Wendt, M.D.,Zhao, X.
Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47:303-324, 2004
PubMed: 14711304
DOI: 110.1021/jm0300072
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.61 Å)
Structure validation
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PDB entries from 2021-06-16