1OWE

Substituted 2-Naphthamidine inhibitors of urokinase

Summary for 1OWE

Related1FV9 1OWD 1OWH 1OWI 1OWJ 1OWK
DescriptorUrokinase-type plasminogen activator, SULFATE ION, 6-[(Z)-AMINO(IMINO)METHYL]-N-PHENYL-2-NAPHTHAMIDE, ... (4 entities in total)
Functional Keywordsplasminogen activation, hydrolase, serine protease, glycoprotein, kringle, egf-like domain
Biological sourceHomo sapiens (human)
Cellular locationSecreted P00749
Total number of polymer chains1
Total molecular weight28214.04
Authors
Wendt, M.D.,Rockway, T.W.,Geyer, A.,McClellan, W.,Weitzberg, M.,Zhao, X.,Mantei, R.,Nienaber, V.L.,Stewart, K.,Klinghofer, V.,Giranda, V.L. (deposition date: 2003-03-28, release date: 2003-09-30, Last modification date: 2017-10-11)
Primary citation
Wendt, M.D.,Rockway, T.W.,Geyer, A.,McClellan, W.,Weitzberg, M.,Zhao, X.,Mantei, R.,Nienaber, V.L.,Stewart, K.,Klinghofer, V.,Giranda, V.L.
Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47:303-324, 2004
PubMed: 14711304 (PDB entries with the same primary citation)
DOI: 10.1021/jm0300072
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2308 0.4% 1.9% 4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
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PDB entries from 2020-09-23