1ORF

The Oligomeric Structure of Human Granzyme A Reveals the Molecular Determinants of Substrate Specificity

Summary for 1ORF

Entry DOI	10.2210/pdb1orf/pdb
Related PRD ID	PRD_000020
Descriptor	Granzyme A, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Isoform alpha: Secreted: P12544
Total number of polymer chains	1
Total formula weight	26420.11
Authors	Bell, J.K.,Goetz, D.H.,Mahrus, S.,Harris, J.L.,Fletterick, R.J.,Craik, C.S. (deposition date: 2003-03-12, release date: 2003-07-01, Last modification date: 2024-03-13)
Primary citation	Bell, J.K.,Goetz, D.H.,Mahrus, S.,Harris, J.L.,Fletterick, R.J.,Craik, C.S. The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nat.Struct.Biol., 10:527-534, 2003 Cited by PubMed: 12819769 DOI: 10.1038/nsb944 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation