1ORF
The Oligomeric Structure of Human Granzyme A Reveals the Molecular Determinants of Substrate Specificity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Granzyme A | polymer | 234 | 25870.1 | 1 | UniProt (P12544) Pfam (PF00089) | Homo sapiens (human) | Cytotoxic T-lymphocyte proteinase 1, Hanukkah factor, H factor, HF, Granzyme 1, CTL tryptase, Fragmentin 1 |
| 2 | B (A) | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide | non-polymer | 454.0 | 1 | BIRD (PRD_000020) Chemie (0G6) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D (A) | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A: 16 - 246 (UniProt: P12544)
| PDB | External Database | Details |
|---|---|---|
| Glu 157 | Asn 170 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 25870.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 550.0 | |
| All* | Total formula weight | 26420.1 |
