1ORF

The Oligomeric Structure of Human Granzyme A Reveals the Molecular Determinants of Substrate Specificity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001772	cellular_component	immunological synapse
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0006915	biological_process	apoptotic process
A	0006955	biological_process	immune response
A	0008236	molecular_function	serine-type peptidase activity
A	0009617	biological_process	response to bacterium
A	0031640	biological_process	killing of cells of another organism
A	0032078	biological_process	negative regulation of endodeoxyribonuclease activity
A	0042803	molecular_function	protein homodimerization activity
A	0043065	biological_process	positive regulation of apoptotic process
A	0043392	biological_process	negative regulation of DNA binding
A	0051354	biological_process	negative regulation of oxidoreductase activity
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0051604	biological_process	protein maturation
A	0070269	biological_process	pyroptotic inflammatory response
A	0140507	biological_process	granzyme-mediated programmed cell death signaling pathway
A	1902483	biological_process	cytotoxic T cell pyroptotic cell death

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 0G6 A 1

Chain	Residue
A	HIS57
A	GLU218
A	GLY226
A	HOH272
A	HOH372
A	HOH373
A	HOH374
A	HOH375
A	ASP189
A	SER190
A	CYS191
A	GLY193
A	SER195
A	SER214
A	PHE215
A	GLY216

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 247

Chain	Residue
A	SER184
A	LEU185
A	ARG186
A	ARG188
A	HOH306

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScnGDSGSPLL

Chain	Residue	Details
A	ASP189-LEU200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:12819769, ECO:0000269|PubMed:12819770

Chain	Residue	Details
A	HIS57
A	ASP102

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:12819769, ECO:0000269|PubMed:12819770, ECO:0000305|PubMed:32299851

Chain	Residue	Details
A	SER195

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	GLU159

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	HIS57

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	SER195
A	GLY196

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site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	SER195
A	GLY193

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site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	SER195
A	HIS57

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site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	SER195
A	GLY193
A	HIS57

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site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	SER195
A	HIS57
A	GLY196

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