1OKZ

Structure of human PDK1 kinase domain in complex with UCN-01

1OKZ の概要

• エントリーDOI: 10.2210/pdb1okz/pdb
• 関連するPDBエントリー: 1H1W 1OKY 1UU3 1UU7 1UU8 1UU9 1UVR
• 分子名称: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: protein kinase, pkb, pdk1, ucn-01, 7-hydroxy staurosporine, inhibitor, transferase, atp-binding, phosphorylation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37014.10

構造登録者

Komander, D.,Kular, G.S.,Alessi, D.R.,Van Aalten, D.M.F. (登録日: 2003-08-01, 公開日: 2004-07-29, 最終更新日: 2023-12-13)

• 主引用文献: Komander, D.,Kular, G.S.,Bain, J.,Elliot, M.,Alessi, D.R.,Van Aalten, D.M.F.; Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition; Biochem.J., 375:255-, 2003; PubMed: 12892559; DOI: 10.1042/BJ20031119

実験手法

X-RAY DIFFRACTION (2.51 Å)