1OHW

4-AMINOBUTYRATE-AMINOTRANSFERASE inactivated by gamma-vinyl GABA

Summary for 1OHW

Related1OHV 1OHY
Descriptor4-AMINOBUTYRATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, 4-AMINO HEXANOIC ACID, ... (5 entities in total)
Functional Keywordstransferase, plp-dependent enzyme, aminotransferase, 4- aminobutyric acid, antiepileptic drug target, vigabatrin pyridoxal phosphate, neurotransmitter degradation, mitochondrion, transit peptide
Biological sourceSUS SCROFA (PIG)
Cellular locationMitochondrion matrix P80147
Total number of polymer chains4
Total molecular weight215340.88
Authors
Storici, P.,Schirmer, T. (deposition date: 2003-06-03, release date: 2003-10-16, Last modification date: 2011-07-13)
Primary citation
Storici, P.,De Biase, D.,Bossa, F.,Bruno, S.,Mozzarelli, A.,Peneff, C.,Silverman, R.,Schirmer, T.
Structures of {Gamma}-Aminobutyric Acid (Gaba) Aminotransferase, a Pyridoxal 5'-Phosphate, and [2Fe-2S] Cluster-Containing Enzyme, Complexed with {Gamma}-Ethynyl-Gaba and with the Antiepilepsy Drug Vigabatrin
J.Biol.Chem., 279:363-, 2004
PubMed: 14534310 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M305884200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers30.2%3.9%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 1ohw
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More Biological unit images

Molmil generated image of 1ohw
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Molmil generated image of 1ohw
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Molmil generated image of 1ohw
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1ohw.pdb1.gz [151.12 KB])
Coordinate files for Biological unit (1ohw.pdb2.gz [151.89 KB])