1OHY

4-AMINOBUTYRATE-AMINOTRANSFERASE inactivated by gamma-ethynyl GABA

Summary for 1OHY

Related1OHV 1OHW
Descriptor4-AMINOBUTYRATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, (4E)-4-AMINOHEX-4-ENOIC ACID, ... (5 entities in total)
Functional Keywordstransferase, plp-dependent enzyme, aminotransferase, 4- aminobutyric acid, antiepileptic drug target, vigabatrin pyridoxal phosphate, neurotransmitter degradation, mitochondrion, transit peptide
Biological sourceSUS SCROFA (PIG)
Cellular locationMitochondrion matrix P80147
Total number of polymer chains4
Total molecular weight215332.82
Authors
Storici, P.,Schirmer, T. (deposition date: 2003-06-03, release date: 2003-10-16, Last modification date: 2011-07-13)
Primary citation
Storici, P.,De Biase, D.,Bossa, F.,Bruno, S.,Mozzarelli, A.,Peneff, C.,Silverman, R.,Schirmer, T.
Structures of {Gamma}-Aminobutyric Acid (Gaba) Aminotransferase, a Pyridoxal 5'-Phosphate, and [2Fe-2S] Cluster-Containing Enzyme, Complexed with {Gamma}-Ethynyl-Gaba and with the Antiepilepsy Drug Vigabatrin
J.Biol.Chem., 279:363-, 2004
PubMed: 14534310 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M305884200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers50.2%4.6%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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