1OHY

4-AMINOBUTYRATE-AMINOTRANSFERASE inactivated by gamma-ethynyl GABA

Summary for 1OHY

Entry DOI	10.2210/pdb1ohy/pdb
Related	1OHV 1OHW
Descriptor	4-AMINOBUTYRATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, (4E)-4-AMINOHEX-4-ENOIC ACID, ... (5 entities in total)
Functional Keywords	transferase, plp-dependent enzyme, aminotransferase, 4- aminobutyric acid, antiepileptic drug target, vigabatrin pyridoxal phosphate, neurotransmitter degradation, mitochondrion, transit peptide
Biological source	SUS SCROFA (PIG)
Cellular location	Mitochondrion matrix: P80147
Total number of polymer chains	4
Total formula weight	215332.82
Authors	Storici, P.,Schirmer, T. (deposition date: 2003-06-03, release date: 2003-10-16, Last modification date: 2011-07-13)
Primary citation	Storici, P.,De Biase, D.,Bossa, F.,Bruno, S.,Mozzarelli, A.,Peneff, C.,Silverman, R.,Schirmer, T. Structures of {Gamma}-Aminobutyric Acid (Gaba) Aminotransferase, a Pyridoxal 5'-Phosphate, and [2Fe-2S] Cluster-Containing Enzyme, Complexed with {Gamma}-Ethynyl-Gaba and with the Antiepilepsy Drug Vigabatrin J.Biol.Chem., 279:363-, 2004 Cited by PubMed: 14534310 DOI: 10.1074/JBC.M305884200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation