1OF1
KINETICS AND CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE INTERACTING WITH (SOUTH)-METHANOCARBA-THYMIDINE
Summary for 1OF1
Entry DOI | 10.2210/pdb1of1/pdb |
Related | 1E2H 1E2I 1E2J 1E2K 1E2L 1E2M 1E2N 1E2P 1KI2 1KI3 1KI4 1KI6 1KI7 1KI8 1QHI 1VTK 2KI5 3VTK |
Descriptor | THYMIDINE KINASE, (SOUTH)-METHANOCARBA-THYMIDINE, SULFATE ION, ... (4 entities in total) |
Functional Keywords | transferase, thymidine kinase, antiviral drug, enzyme-prodrug gene, kinase, dna synthesis, atp-binding |
Biological source | HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17) |
Total number of polymer chains | 2 |
Total formula weight | 82732.41 |
Authors | Claus, M.T.,Schelling, P.,Folkers, G.,Marquez, V.E.,Scapozza, L.,Schulz, G.E. (deposition date: 2003-04-03, release date: 2004-06-03, Last modification date: 2023-12-13) |
Primary citation | Schelling, P.,Claus, M.T.,Johner, R.,Marquez, V.E.,Schulz, G.E.,Scapozza, L. Biochemical and Structural Characterization of (South)-Methanocarbathymidine that Specifically Inhibits Growth of Herpes Simplex Virus Type 1 Thymidine Kinase-Transduced Osteosarcoma Cells J.Biol.Chem., 279:32832-, 2004 Cited by PubMed: 15163659DOI: 10.1074/JBC.M313343200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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