Crystal Structure of the CUB1-EGF Interaction Domain of Complement Protease C1s

Summary for 1NZI

DescriptorComplement C1s component, CALCIUM ION, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordscalcium, complement, innate immunity, modular structure, cub, egf, hydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight36418.56
Gregory, L.A.,Thielens, N.M.,Arlaud, G.J.,Fontecilla-Camps, J.C.,Gaboriaud, C. (deposition date: 2003-02-18, release date: 2003-06-10, Last modification date: 2011-07-13)
Primary citation
Gregory, L.A.,Thielens, N.M.,Arlaud, G.J.,Fontecilla-Camps, J.C.,Gaboriaud, C.
X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement
J.Biol.Chem., 278:32157-32164, 2003
PubMed: 12788922 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M305175200
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.238601.8%4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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