1NZI
Crystal Structure of the CUB1-EGF Interaction Domain of Complement Protease C1s
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 1001 |
| Chain | Residue |
| A | ASP116 |
| A | ILE117 |
| A | GLU119 |
| A | ASN134 |
| A | PHE135 |
| A | GLY138 |
| A | HOH1005 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 1002 |
| Chain | Residue |
| B | GLU119 |
| B | ASN134 |
| B | PHE135 |
| B | GLY138 |
| B | HOH1010 |
| B | ASP116 |
| B | ILE117 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1003 |
| Chain | Residue |
| A | GLU45 |
| A | ASP53 |
| A | ASP98 |
| A | HOH1109 |
| A | HOH1110 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1004 |
| Chain | Residue |
| B | GLU45 |
| B | ASP53 |
| B | ASP98 |
| B | HOH1122 |
| B | HOH1134 |
Functional Information from PROSITE/UniProt
| site_id | PS00010 |
| Number of Residues | 12 |
| Details | ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CnNfiggYfCsC |
| Chain | Residue | Details |
| A | CYS132-CYS143 |
| site_id | PS01187 |
| Number of Residues | 26 |
| Details | EGF_CA Calcium-binding EGF-like domain signature. DiNECtdfvdvp.......Cshf....CnNfiggYfC |
| Chain | Residue | Details |
| A | ASP116-CYS141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12788922","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23922389","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29311313","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NZI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"(3R)-3-hydroxyasparagine","evidences":[{"source":"PubMed","id":"2141278","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2141278","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23922389","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 41 |
| Details | Domain: {"description":"EGF-like; calcium-binding"} |
| Chain | Residue | Details |
