1NVU

Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS

1NVU の概要

• エントリーDOI: 10.2210/pdb1nvu/pdb
• 関連するPDBエントリー: 1BDK 1NVV 1NVW 1NVX
• 分子名称: Transforming protein p21/H-RAS-1, Son of sevenless protein homolog 1, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: proto-oncogene, gtp binding, guanine nucleotide release factor, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Lipid-anchor; Cytoplasmic side: P01112
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 95277.40

構造登録者

Margarit, S.M.,Sondermann, H.,Hall, B.E.,Nagar, B.,Hoelz, A.,Pirruccello, M.,Bar-Sagi, D.,Kuriyan, J. (登録日: 2003-02-04, 公開日: 2003-04-01, 最終更新日: 2023-08-16)

• 主引用文献: Margarit, S.M.,Sondermann, H.,Hall, B.E.,Nagar, B.,Hoelz, A.,Pirruccello, M.,Bar-Sagi, D.,Kuriyan, J.; Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS; Cell(Cambridge,Mass.), 112:685-695, 2003; PubMed: 12628188; DOI: 10.1016/S0092-8674(03)00149-1

実験手法

X-RAY DIFFRACTION (2.2 Å)