1NI4

HUMAN PYRUVATE DEHYDROGENASE

Summary for 1NI4

• Entry DOI: 10.2210/pdb1ni4/pdb
• Descriptor: Pyruvate dehydrogenase E1 component: Alpha subunit, Pyruvate dehydrogenase E1 component: Beta subunit, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: thiamin pyrophosphate, pyruvate, alpha-keto acid dehydrogenase, pyruvate dehydrogenase, oxidoreductase
• Biological source: Homo sapiens (human); More
• Cellular location: Mitochondrion matrix: P08559 P11177
• Total number of polymer chains: 4
• Total formula weight: 159444.81

Authors

Ciszak, E.,Korotchkina, L.G.,Dominiak, P.M.,Sidhu, S.,Patel, M.S. (deposition date: 2002-12-20, release date: 2003-06-17, Last modification date: 2011-07-13)

• Primary citation: Ciszak, E.M.,Korotchkina, L.G.,Dominiak, P.M.,Sidhu, S.,Patel, M.S.; Structural Basis for Flip-Flop Action of Thiamin Pyrophosphate-Dependent Enzymes Revealed by Human Pyruvate Dehydrogenase; J.Biol.Chem., 278:21240-21246, 2003; PubMed: 12651851; DOI: 10.1074/jbc.M300339200

Experimental method

X-RAY DIFFRACTION (1.95 Å)