1NI4
HUMAN PYRUVATE DEHYDROGENASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004738 | molecular_function | pyruvate dehydrogenase activity |
| A | 0004739 | molecular_function | pyruvate dehydrogenase (acetyl-transferring) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| A | 0034604 | molecular_function | pyruvate dehydrogenase (NAD+) activity |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| A | 1902494 | cellular_component | catalytic complex |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004739 | molecular_function | pyruvate dehydrogenase (acetyl-transferring) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0034604 | molecular_function | pyruvate dehydrogenase (NAD+) activity |
| B | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| C | 0004738 | molecular_function | pyruvate dehydrogenase activity |
| C | 0004739 | molecular_function | pyruvate dehydrogenase (acetyl-transferring) activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005730 | cellular_component | nucleolus |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0006006 | biological_process | glucose metabolic process |
| C | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
| C | 0006090 | biological_process | pyruvate metabolic process |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| C | 0034604 | molecular_function | pyruvate dehydrogenase (NAD+) activity |
| C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| C | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| C | 1902494 | cellular_component | catalytic complex |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004739 | molecular_function | pyruvate dehydrogenase (acetyl-transferring) activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0006006 | biological_process | glucose metabolic process |
| D | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0034604 | molecular_function | pyruvate dehydrogenase (NAD+) activity |
| D | 0045254 | cellular_component | pyruvate dehydrogenase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1331 |
| Chain | Residue |
| C | ASP167 |
| C | ASN196 |
| C | TYR198 |
| C | TPP1330 |
| C | HOH2332 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 1332 |
| Chain | Residue |
| B | HOH1333 |
| B | ILE112 |
| B | ALA160 |
| B | ASP163 |
| B | ASN165 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 2331 |
| Chain | Residue |
| A | ASP167 |
| A | ASN196 |
| A | TYR198 |
| A | TPP2330 |
| A | HOH2331 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K D 2332 |
| Chain | Residue |
| D | ILE112 |
| D | ALA160 |
| D | ASP163 |
| D | ASN165 |
| D | HOH2334 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE TPP C 1330 |
| Chain | Residue |
| A | MG1331 |
| B | GLU28 |
| B | ILE57 |
| B | GLU59 |
| B | PHE85 |
| B | GLN88 |
| C | TYR89 |
| C | ARG90 |
| C | GLY136 |
| C | VAL138 |
| C | GLY166 |
| C | ASP167 |
| C | GLY168 |
| C | ALA169 |
| C | ASN196 |
| C | TYR198 |
| C | GLY199 |
| C | HIS263 |
| C | HOH2333 |
| C | HOH2334 |
| C | HOH2335 |
| C | HOH2336 |
| site_id | AC6 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE TPP A 2330 |
| Chain | Residue |
| A | TYR89 |
| A | ARG90 |
| A | GLY136 |
| A | VAL138 |
| A | GLY166 |
| A | ASP167 |
| A | GLY168 |
| A | ALA169 |
| A | ASN196 |
| A | TYR198 |
| A | GLY199 |
| A | HIS263 |
| A | HOH2332 |
| A | HOH2333 |
| A | HOH2334 |
| A | HOH2335 |
| C | MG2331 |
| D | GLU28 |
| D | ILE57 |
| D | GLU59 |
| D | PHE85 |
| D | GLN88 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12651851 |
| Chain | Residue | Details |
| B | SER58 | |
| D | SER58 | |
| A | LYS284 | |
| C | LYS34 | |
| C | LYS215 | |
| C | LYS284 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Important for interaction with DLAT => ECO:0000269|PubMed:20160912 |
| Chain | Residue | Details |
| B | LEU288 | |
| D | LEU288 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9D051 |
| Chain | Residue | Details |
| B | ALA36 | |
| D | ALA36 | |
| C | LYS248 | |
| C | LYS356 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9D051 |
| Chain | Residue | Details |
| B | ILE323 | |
| D | ILE323 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P35486 |
| Chain | Residue | Details |
| A | SER266 | |
| C | SER266 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PDK1, PDK2, PDK3 and PDK4 => ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:19081061 |
| Chain | Residue | Details |
| A | SER271 | |
| C | SER271 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P35486 |
| Chain | Residue | Details |
| A | TYR272 | |
| C | TYR272 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS292 | |
| C | LYS292 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P35486 |
| Chain | Residue | Details |
| A | LYS307 | |
| C | LYS307 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | a catalytic site defined by CSA, PubMed 9655909, 10426958, 12651851, 12795594 |
| Chain | Residue | Details |
| C | HIS263 | |
| B | GLU59 | |
| B | HIS128 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | a catalytic site defined by CSA, PubMed 9655909, 10426958, 12651851, 12795594 |
| Chain | Residue | Details |
| A | HIS263 | |
| D | GLU59 | |
| D | HIS128 |
